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KMID : 0869120120140020129
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기초간호자연과학회지
2012 Volume.14 No. 2 p.129 ~ p.138
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Safe Nuclear Factor-kappa B Inhibitor for Cachexia Management
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Park Jeong-Soo
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Abstract
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Purpose: Cachexia is a complex metabolic syndrome associated with wasting of skeletal muscle which contributes to nearly one-third of all cancer deaths. Cachexia lowers the frequency of response to chemotherapy and radiation and ultimately can impact survival as well as quality of life during treatment. NF-kappa B is one of the most important molecular mediators of cachexia. In this study, therefore, possible candidates for inhibitors of NF-kappa B were searched.
Methods: Amino acids that regulate cellular redox potential by adjusting the level of NAD/NADH ratio, such as aspartate, pyruvate, and isocitrate were selected.
Results: Pyruvate effectively inhibited luciferase activity in TNF-stimulated 293T cells transfect with an NF-kB dependent luciferase reporter vector. Pyruvate also showed protective effect on muscle atrophy of differentiated C2C12 myocyte induced by TNF/IFN.
Conclusion: We might be able to develop the nutritional management strategy for cancer cachexia patients with pyruvate supplementation.
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KEYWORD
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NF-κB, Pyruvate, Cachexia, Cancer patient nursing, Nutrition,
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